Prof. Dr. med. Bernd Limberg
Facharzt für Innere Medizin - Gastroenterologie
Gastroenterologische Privatpraxis

Ärztehaus am Theater
Steinweg 26
38100 Braunschweig
Tel: 0531 2434225
Fax: 0531 2434229
Sprechzeiten nach Vereinbarung

Einführung / Introduction

EFSUMB Recommendations and Clinical Guidelines for Intestinal Ultrasound (GIUS) in Inflammatory Bowel Diseases.
Maconi G, Nylund K, Ripolles T, Calabrese E, Dirks K, Dietrich CF, Hollerweger A, Sporea I, Saftoiu A, Maaser C, Hausken T, Higginson AP, Nürnberg D, Pallotta N, Romanini L, Serra C, Gilja OH.
Ultraschall Med. 2018 Jun;39(3):304-317. doi: 10.1055/s-0043-125329. Epub 2018 Mar 22.
PMID: 29566419 English.

GIUS is recommended to be used to detect IBD at its first presentation, and to assess CD location, activity and possible complications [LoE 1a, GoR A]. Consensus levels of agreement: A+ 17/17; Semi-quantitative assessment of bowel wall vascularity using color Doppler techniques is useful to evaluate Crohn’s disease activity [LoE 2b, GoR B]

Der Limberg-Score / The Limberg-Score

Der Artikel "Diagnostik von chronisch-entzündlichen Darmerkrankungen durch Sonographie" [en: "Diagnosis of chronic inflammatory bowel diseases by ultrasonography", download link below], Z Gastroenterol. 1999; 37: 495-508, in dem der Limberg-Score erstmals Erwähnung findet, ist unter folgendem Link vollständig abrufbar:

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Weiterführende Links & Quellen / Additional References & Sources

Diagnosis and differential diagnosis of ulcerative colitis and Crohn's disease by hydrocolonic sonography.
Limberg B, Osswald B.
Am J Gastroenterol. 1994 Jul;89(7):1051-7.
PMID: 8017364

Sonographie des Gastrointestinaltrakts
Limberg B
Springer Verlag, Berlin Heidelberg New York 1998
ISBN 978-3-642-93575-6

Diagnosis of chronic inflammatory bowel disease by ultrasonography.
Limberg B.
Z Gastroenterol. 1999 Jun;37(6):495-508.
PMID: 10427656 German.

Intestinal wall vascularisation in Crohn's disease.
Kratzer W, Foeller T, Kaechele V, Reinshagen M, Tirpitz CV, Haenle MM.
Z Gastroenterol. 2004 Sep;42(9):973-8. doi: 10.1055/s-2004-813352.
PMID: 15455266 German.

Comparison of sonographically measured bowel wall vascularity, histology, and disease activity in Crohn's disease.
Drews BH, Barth TF, Hänle MM, Akinli AS, Mason RA, Muche R, Thiel R, Pauls S, Klaus J, von Boyen G, Kratzer W.
Eur Radiol. 2009 Jun;19(6):1379-86. doi: 10.1007/s00330-008-1290-5. Epub 2009 Jan 30.
PMID: 19184036

Assessment of inflammatory and fibrotic stenoses in patients with Crohn's disease using contrast-enhanced ultrasound and computerized algorithm: a pilot study.
Schirin-Sokhan R, Winograd R, Tischendorf S, Wasmuth HE, Streetz K, Tacke F, Trautwein C, Tischendorf JJ.
Digestion. 2011;83(4):263-8. doi: 10.1159/000321389. Epub 2011 Jan 28.
PMID: 21273775

Use of color Doppler ultrasonography for evaluating vascularity of small intestinal lesions in Crohn's disease: correlation with endoscopic and surgical macroscopic findings.
Sasaki T, Kunisaki R, Kinoshita H, Yamamoto H, Kimura H, Hanzawa A, Shibata N, Yonezawa H, Miyajima E, Sakamaki K, Numata K, Tanaka K, Maeda S.
Scand J Gastroenterol. 2014 Mar;49(3):295-301. doi: 10.3109/00365521.2013.871744. Epub 2013 Dec 18.
PMID: 24344807

Doppler ultrasound findings correlate with tissue vascularity and inflammation in surgical pathology specimens from patients with small intestinal Crohn's disease.
Sasaki T, Kunisaki R, Kinoshita H, Kimura H, Kodera T, Nozawa A, Hanzawa A, Shibata N, Yonezawa H, Miyajima E, Morita S, Fujii S, Numata K, Tanaka K, Tanaka M, Maeda S.
BMC Res Notes. 2014 Jun 14;7:363. doi: 10.1186/1756-0500-7-363.
PMID: 24927748

US-based Real-time Elastography for the Detection of Fibrotic Gut Tissue in Patients with Stricturing Crohn Disease.
Baumgart DC, Müller HP, Grittner U, Metzke D, Fischer A, Guckelberger O, Pascher A, Sack I, Vieth M, Rudolph B.
Radiology. 2015 Jun;275(3):889-99. doi: 10.1148/radiol.14141929. Epub 2015 Feb 6.
PMID: 25668520

Use of Intestinal Ultrasound to Monitor Crohn's Disease Activity.
Kucharzik T, Wittig BM, Helwig U, Börner N, Rössler A, Rath S, Maaser C; TRUST study group.
Clin Gastroenterol Hepatol. 2017 Apr;15(4):535-542.e2. doi: 10.1016/j.cgh.2016.10.040. Epub 2016 Nov 14.
PMID: 27856365

Acoustic radiation force impulse (ARFI) elastography of the bowel wall as a possible marker of inflammatory activity in patients with Crohn's disease.
Goertz RS, Lueke C, Wildner D, Vitali F, Neurath MF, Strobel D.
Clin Radiol. 2018 Jul;73(7):678.e1-678.e5. doi: 10.1016/j.crad.2018.02.005. Epub 2018 Mar 14.
PMID: 29549998

Correlation between ultrasound consolidated score and simple endoscopic score for determining the activity of Crohn's disease.
Liu C, Ding SS, Zhang K, Liu LN, Guo LH, Sun LP, Zhang YF, Sun XM, Ren WW, Zhao CK, Li XL, Wang Q, Xu XR, Xu HX.
Br J Radiol. 2020 May 1;93(1109):20190614. doi: 10.1259/bjr.20190614. Epub 2020 Feb 28.
PMID: 32101466